Students:
Abeer Madi
Ehab abu Haija
Israa Sabneh
Supervisor
Dr. Asma Hasan
Abstract
Background : Drug-drug interactions (DDIs) are of special concern since it may reduce the therapeutic effectiveness of the drug or may lead to toxicity. Tetracycline is well known for its interactions with metallic containing food and antacids.
Objectives : The aim of the current study was to mechanistically demonstrate the interactions of doxycycline with Maalox plus® antacid and Calcimor® antacid using in vitro and in silico techniques.
Methods : In this study ,dissolution , disintegration and solubility of doxal® in media with / without antacid were determined. In silico techniques were used to build a model to simulate the Gastrointestinal absorption of doxal alone using Gastro Plus software.
Result : Solubility, disintegrates rates as well as drug release rates were reduced in the presence of antacids compared to media without antacid. The effect was more pronounced for Maloox plus ®antacid. This can be attributed to the formation of insoluble complex between the drug and the metals.
Conclusion : In conclusion, doxycycline should be given at least 2 h before the antacid to ensure sufficient therapeutic efficacy of the drug.
