Students:
Afnan Raddad
Alaa Rashed
Amneh Bsharat
Dania Abu-Ghazaleh
Eman Yasin
Oraina Shehab
Supervisor :
Dr. Rowa' Al-Ramahi
Abstract :
Objectives:the aims of this study are to find the prevalence of potential drug-drug interactions (DDIs) in patients with Hemodialysis and identify factors associated with these interactions if present.
Method:the study was an observational- retrospective cohort study that was conducted in ten hemodialysis units in the West bank, Palestine, between June and August 2015. The data collection form was completed by interviewing the patients in addition to reviewing their medical records. Potential DDIs were reviewed. SPSS program was used for data analysis.
Results:The study included 275 patients, a total of 930 interactions were identified in 245 (89.1%) patients. Out of which, 713 (76.7%) were moderate in severity, 160 (17.2%) were minor, 55 (5.9%) were major. Patients were prescribed 1-15 drugs with a mean (± SD) of 7.87 ±2.44, calcium carbonate was the most common drug prescribed. The most common interaction in 114 (41.5%) patients was Calcium Carbonate / Amlodipine followed by Calcium Carbonate / Aspirin in 76 (27.6%) cases. Most patients (89.9%) of the patients had one or more comorbid diseases; hypertension, diabetes and gout were the most common. The number of DDIs that the patients had were related to the number of diseases, the number of prescribed drugs (P value <0.0001). Also number of DDIs were related to age of the patients (P value = 0.015).
Conclusion:The prevalence of drug- drug interactions among hemodialysis patients is very common; it is highly expected and depends on the number of drugs taken by the patients. Many of these interactions are considered as preventable drug- related problems, so screening for potential interactions and monitoring regularly is highly needed.
