This course will discuss principles of clinical pharmacokinetics and their application to the therapy of various states of disease. Changes in pharmacokinetic parameters due to diseases and therapeutic drug monitoring are also discussed. The course will also provide the student with literature review of the pharmacokinetic parameters for many of the most commonly monitored drugs. The principles of Therapeutic Drug Monitoring (TDM) will be emphasized through effective use of class lectures, presentations and referring to patients’ records to present it as case studies. Such presentations and case studies will be steered so that it will emphasize the need to obtain accurate plasma level measurements in such a way that patient-specific pharmacokinetic parameters can be derived and to appreciate the degree of inter- and intra-subject variability.
